Prenatal diagnosis using array comparative genomic hybridization analysis in high risk of the first trimmest combined test and structure anomalies

Methods From January 2013 to December 2015, we included 107 chorionic villus sampling sample from consecutive ongoing gestation, with combine test risk >1/270, fetal NT˃3. 5mm, NB(-), DV(+), TR(+) and structure abnormalities at 11-13 weeks' gestation, from a regional hospital. Subsequently, 93 amniocentesis sampling was performed when the structure abnormalities finding by ultrasonography scans at 18-22 weeks. Both of G-banding karyotype and CMA are parallel performed. DNA was extracted directed from the samples and examination with 60kb oligonucleotide array-based comparative genomic hybridization (n=200).